ea0039oc7.5 | Oral Communications 7 | BSPED2015
Donnelly Catherine
, Williams Alistair
Background: Post-translational modification (PTM) of antigens has been shown to play a role in the pathogenesis of autoimmune disorders. In coeliac disease (CD), tissue transglutaminase (tTG) deamidates gliadin peptides to activate the immune response against gut endomysium. CD is six times more prevalent in Type 1 diabetes (T1D) patients than in the general population.Hypothesis: tTG also modifies auto-antigens implicated in the pathogenesis of T1D, lea...